Statistically significant between-group and within-group grey matter volumetric associations in patients with functional neurological disorder and healthy controls
| Analysis | Measures of interest | Cerebral regions (Brodmann area) | Peak coordinates in MNI Space (mm) | Peak voxel Z-score | p Value (SVC) | Cluster extent (mm3) | ||
| x | y | z | ||||||
| Between group | Poor physical health 13 FND <27 HC | L anterior insula (48) | −42 | 14 | −3 | −4.25 | <0.001 (0.007) | 342 |
| Poor mental health 13 FND>27 HC | R cerebellum, crus I | 36 | −58 | −36 | 4.80 | <0.001 (0.036*) | 1453 | |
| Within group | Impaired mental health positive associations | R amygdala (34) | 28 | −1 | −18 | 3.90 | <0.001 (0.004) | 415 |
| STAI-Trait anxiety positive associations | R amygdala (34) | 21 | −1 | −17 | 3.46 | <0.001 (0.018) | 132 | |
| Impaired emotional well-being positive associations | R amygdala (34) | 27 | −1 | −18 | 3.54 | <0.001 (0.014) | 170 | |
| Role limitations due to emotional problems positive associations | R amygdala (20) | 30 | −3 | −20 | 4.56 | <0.001 (<0.001) | 1018 | |
| Periaqueductal grey | −3 | −37 | −12 | 4.12 | <0.001 (0.003) | 534 | ||
| L amygdala/anterior hippocampus (20) | −27 | −6 | −18 | 3.29 | <0.001 (0.030) | 596 | ||
| Impaired physical functioning negative associations | L anterior insula (48) | −39 | 8 | −11 | −3.78 | <0.001 (0.039) | 179 | |
Note: Physical and mental health are based on the two composite categories of the Short Form Health Survey-36 (SF-36). The ‘emotional well-being’, ‘role limitations due to emotional problems’, and ‘physical functioning’ measures are individual subscales of the SF-36. All SF-36 scores were inverted so that higher scores represent worse health status.
*Denotes whole-brain corrected p value.
FND, functional neurological disorder; HC, healthy controls; L, left; MNI, Montreal Neurological Institute; R, right; STAI-Trait Anxiety, Spielberger Trait Anxiety Inventory; SVC, small volume corrected.