Table 1

Controversies and priorities in multifocal motor neuropathy (MMN)

Diagnosis

  • What is the role for nerve MRI and ultrasound?

  • Can a patient have MMN despite the lack of conduction block identified on comprehensive routine neurophysiological testing?

Pathophysiology

  • Is MMN an axonal or demyelinating neuropathy?

  • Is MMN a nodo-paranodopathy?

  • Are anti-GM1 IgM antibodies pathogenic or a bystander?

  • Are there other relevant antibodies when anti-GM1 is negative?

Treatment

  • What are other treatment options apart from intravenous immunoglobulin?

  • What are current treatment recommendations based on the available evidence?