Table 3

Linear mixed models reflecting the change in visual outcomes based on the change in BPF, GMF and T2LV

Visual test	Slope (β)	SE	95% CI	P value
√FM error
T2LV	0.066	0.03	0.0064 to 0.13	0.031*
BPF	−7.91	7.55	−22.93 to 7.11	0.29
GMF	−5.95	11.61	−28.24 to 17.63	0.61
WMF	12.6	14.86	−17.12 to 41.73	0.40
Sloan 2.5%
T2LV	0.085	0.11	−0.13 to 0.30	0.43
BPF	40.7	26.61	−12.17 to 93.56	0.13
GMF	63.19	41.75	−19.8 to 146.18	0.13
WMF	26.55	54.63	−82.03 to 135.13	0.63
Sloan 1.25%
T2LV	−0.047	0.11	−0.26 to 0.17	0.66
BPF	20.64	26.53	−32.07 to 73.34	0.44
GMF	8.54	41.7	−74.35 to 91.42	0.83
WMF	15.8	54.55	−92.63 to 124.22	0.77
LogMAR
T2LV	0.00076	0.0013	−0.0017 to 0.0033	0.55
BPF	−0.70	0.31	−1.31 to −0.080	0.027*
GMF	0.88	0.49	−1.85 to 0.084	0.073
WMF	−0.010	0.64	−1.27 to 1.25	0.99

Models corrected for age, sex, history of optic neuritis and multiple sclerosis phenotype.
* denotes a statistical significance p-value <0.05
BPF, brain parenchymal fraction ; GMF, grey matter fraction; T2LV, T2 lesion volume ; WMF, white matter fraction.