Cluster information displaying the interaction between sex and Framingham risk score, abdominal subcutaneous adipose tissue volume, and visceral adipose tissue volume with lower brain volume
| Decade (ages) | Total volume (voxels) | Percentage of total grey matter mask | Maximum T value | Peak regional associations |
| Framingham risk scores | ||||
| 55–64 | 82 905 | 42% | −6.7 | Frontal pole, planum temporale, temporal occipital fusiform cortex |
| 65–75 | 9229 | 5% | −5.35 | Juxtapositional lobule cortex, temporal fusiform cortex, frontal pole |
| Abdominal subcutaneous adipose tissue | ||||
| 45–54 | 36 118 | 18% | −6.06 | Temporal pole, frontal medial cortex, planum polare, occipital pole |
| 55–64 | 18 471 | 9% | −7.19 | Frontal pole, superior temporal gyrus, precentral gyrus, postcentral gyrus |
| 65–74 | 15 090 | 8% | −6.6 | Frontal pole, precentral gyrus, inferior temporal gyrus, anterior cingulate cortex |
| 75+ | 5854 | 3% | 6.18 | Inferior temporal gyrus, occipital pole |
| Visceral adipose tissue | ||||
| 45–54 | 16 748 | 8% | −6.97 | Occipital pole, middle frontal gyrus, inferior temporal gyrus, postcentral gyrus |
| 65–74 | 14 397 | 7% | 6.81 | Occipital pole, precuneous, parahippocampus |