Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study

Dae-Gyu Jang; John F Dou; Emily J Koubek; Samuel Teener; Lili Zhou; Kelly M Bakulski; Bhramar Mukherjee; Stuart A Batterman; Eva L Feldman; Stephen A Goutman

doi:10.1136/jnnp-2024-333978

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Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study

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Dae-Gyu Jang Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
John F Dou Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Emily J Koubek Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Samuel Teener Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Lili Zhou Department of Biostatistics, Corewell Health, Royal Oak, Michigan, USA PubMed articles Google scholar articles
Kelly M Bakulski Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Bhramar Mukherjee Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Stuart A Batterman Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Eva L Feldman Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Stephen A Goutman Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles

Correspondence to Dr Stephen A Goutman; sgoutman{at}med.umich.edu

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Jang D, Dou JF, Koubek EJ, et al

Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study

Journal of Neurology, Neurosurgery & Psychiatry 2025;96:329-339.

Publication history

Received April 8, 2024
Accepted July 15, 2024
First published August 6, 2024.

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March 24, 2025

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